Translational research is an interface between fundamental research at the laboratory and the application in hospitals and university hospitals. This means that laboratory findings that are supposed to be beneficial are applied to patients. The aim is to explore new paths in diagnosis and therapy of certain diseases and to gain new insights into the pathogenesis. Translational research is becoming an increasingly important factor in most medical specialties. Also treatment of cancer depends on results of translational research. A fundamental objective of translational research is the development of a “personalised medicine” which enables therapy to be customised for a certain patient. Thus, not only the disease pattern, but also the individual genetic characteristics of the patient could be taken into account. The long-term aim of personalised medicine is to prevent the application of ineffective pharmaceuticals and to offer an effective therapy, which is customised to the genetic profile of each individual patient, instead. This could help to improve response rates to therapy and reduce side effects.
The complexity of cancer and other diseases requires interdisciplinary collaboration. This means that experts of different specialties work together closely: biologists and biochemists, chemists and bioengineers, pharmacologists and pharmacists, but also statisticians, experts on drug safety, and physicians as well as many other specialists and experts. The importance of translational research is constantly increasing. At the same time, it is vital that patients participate in clinical trials so that the findings can be implemented into the medical standard of care. By participating in the GANNET53 trial, you contribute to translational research.